The national distribution centre will open this summer, and will play a key part in delivering Clothing and Home products to over 98 stores in the South East.
At its peak, the site - operated by DHL - is expected to employ up to 1,000 people.
Rob Davies, Head of Programme Delivery at MS Welham Green said: "Our new Clothing Home distribution centre in Welham Green will not only support our stores in the South East but ensure better availability and choice for our customers."
Mark Defanis, General Manager of the new distribution centre added: "DHL is delighted to be extending its partnership with MS as it enters the next phase of its journey. The new Welham Green distribution centre offers a variety of exciting roles and great prospects for successful candidates."